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Breakthrough Microscopy Reveals Cellular Secrets Without Dyes

11/14/2025

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Summary

Story summary

Researchers at the University of Tokyo developed bidirectional quantitative scattering microscopy (BiQSM) that captures both forward and backward scattered light and visualizes large cellular structures alongside nanoscale particles.
BiQSM yields an intensity range fourteen times broader than conventional microscopes without fluorescent dyes.
The team aims to study exosomes and viruses and to monitor cellular responses during drug treatments.
The findings are published in Nature Communications.

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Story summary

Researchers at the University of Tokyo developed bidirectional quantitative scattering microscopy (BiQSM) that captures both forward and backward scattered light and visualizes large cellular structures alongside nanoscale particles.
BiQSM yields an intensity range fourteen times broader than conventional microscopes without fluorescent dyes.
The team aims to study exosomes and viruses and to monitor cellular responses during drug treatments.
The findings are published in Nature Communications.