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New Studies Uncover Genetic Causes of Pregnancy Loss

11/15/2025

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Summary

Story summary

Pregnancy loss affects up to 25% of pregnancies, mainly in the first trimester, often due to genetic issues.
Researchers from Dartmouth-Hitchcock Medical Center identified an average of 40 structural changes in genomes of patients with recurrent pregnancy loss (RPL) at the Association for Molecular Pathology (AMP) 2025 Annual Meeting.
A separate study from Queens University linked fragile chromosome sites, particularly FRA16B, to RPL, indicating that optical genome mapping (OGM) can detect genetic abnormalities overlooked by traditional tests.

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Story summary

Pregnancy loss affects up to 25% of pregnancies, mainly in the first trimester, often due to genetic issues.
Researchers from Dartmouth-Hitchcock Medical Center identified an average of 40 structural changes in genomes of patients with recurrent pregnancy loss (RPL) at the Association for Molecular Pathology (AMP) 2025 Annual Meeting.
A separate study from Queens University linked fragile chromosome sites, particularly FRA16B, to RPL, indicating that optical genome mapping (OGM) can detect genetic abnormalities overlooked by traditional tests.