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UCSD Researchers Uncover NOD2's Role in Crohn's Disease

11/17/2025

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Summary

Story summary

Researchers at the University of California, San Diego identified NOD2 mutations driving inflammation linked to Crohn's disease and IBD.
Using machine learning, they show NOD2 and girdin cooperate to balance inflammatory and non-inflammatory macrophages in the gut.
This balance is essential for gut health and explains how NOD2 mutations contribute to IBD.
The findings were published in the Journal of Clinical Investigation.

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Story summary

Researchers at the University of California, San Diego identified NOD2 mutations driving inflammation linked to Crohn's disease and IBD.
Using machine learning, they show NOD2 and girdin cooperate to balance inflammatory and non-inflammatory macrophages in the gut.
This balance is essential for gut health and explains how NOD2 mutations contribute to IBD.
The findings were published in the Journal of Clinical Investigation.