Story perspectives

New Genetic Score Revolutionizes Arrhythmia Risk Prediction

11/18/2025

Summary

Story summary

Northwestern Medicine researchers developed a new genetic risk score to predict arrhythmias.
The score integrates monogenic, polygenic testing and whole-genome sequencing for a comprehensive risk view and was published in Cell Reports Medicine on November 11, 2025.
In a study of 523 arrhythmia patients and 596 controls, the method identifies rare mutations and improves predictions.
Genetic testing remains underutilized, with only 1–5% of those who could benefit receiving it.

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Story summary

Northwestern Medicine researchers developed a new genetic risk score to predict arrhythmias.
The score integrates monogenic, polygenic testing and whole-genome sequencing for a comprehensive risk view and was published in Cell Reports Medicine on November 11, 2025.
In a study of 523 arrhythmia patients and 596 controls, the method identifies rare mutations and improves predictions.
Genetic testing remains underutilized, with only 1–5% of those who could benefit receiving it.