Story perspectives

Study Challenges 20-Year Theory on Chromosome Stabilization

11/21/2025

Summary

Story summary

Researchers at the Ruder Boškovic Institute in Zagreb reveal that CENP-E stabilizes initial chromosome connections rather than acting as a motor that pulls chromosomes.
This role ties CENP-E regulation to Aurora kinase activity and helps prevent errors in chromosome segregation.
The findings, published in Nature Communications, challenge more than twenty years of textbook knowledge.
The work was supported by the European Research Council and the Croatian Science Foundation.

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Story summary

Researchers at the Ruder Boškovic Institute in Zagreb reveal that CENP-E stabilizes initial chromosome connections rather than acting as a motor that pulls chromosomes.
This role ties CENP-E regulation to Aurora kinase activity and helps prevent errors in chromosome segregation.
The findings, published in Nature Communications, challenge more than twenty years of textbook knowledge.
The work was supported by the European Research Council and the Croatian Science Foundation.