Story perspectives

Metformin May Hinder Exercise Benefits in Metabolic Risk

11/22/2025

Summary

Story summary

A Rutgers University–led study found that metformin may blunt improvements in vascular insulin sensitivity, aerobic fitness, and fasting glucose during exercise for those at risk of metabolic syndrome.
Participants performing both high- and low-intensity workouts showed diminished gains when taking metformin versus exercise without the drug.
Researchers call for careful consideration of metformin use with exercise and for future studies to develop better guidelines.

1 of 1

Story summary

A Rutgers University–led study found that metformin may blunt improvements in vascular insulin sensitivity, aerobic fitness, and fasting glucose during exercise for those at risk of metabolic syndrome.
Participants performing both high- and low-intensity workouts showed diminished gains when taking metformin versus exercise without the drug.
Researchers call for careful consideration of metformin use with exercise and for future studies to develop better guidelines.