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Pfizer's mRNA Flu Vaccine Shines Amid Skepticism

11/23/2025

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Story summary
  • Pfizer Inc.'s mRNA flu vaccine showed superior effectiveness in a Phase 3 trial of 18,000 adults during 2022-2023.
  • The trial showed a 34.5% reduction in flu-like illnesses, with 57 cases in the mRNA group and 87 in the traditional group.
  • Side effects were more common with the mRNA vaccine, including a higher fever.
  • Experts say approval may face skepticism toward mRNA technology, from officials such as Robert F. Kennedy Jr.