Story perspectives

Breakthrough Study Links GRIN2A Gene to Mental Illness

12/3/2025

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Summary

Story summary

In 2021, the World Health Organization reported that nearly one in seven people worldwide lived with a mental illness.
Professor Johannes Lemke led research identifying the GRIN2A gene as a significant factor in mental illness.
The study analyzed data from 121 individuals with GRIN2A variants.
The data linked variants to early-onset psychiatric symptoms, including schizophrenia.
Initial treatment with L-serine showed improvements in psychiatric symptoms.

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Story summary

In 2021, the World Health Organization reported that nearly one in seven people worldwide lived with a mental illness.
Professor Johannes Lemke led research identifying the GRIN2A gene as a significant factor in mental illness.
The study analyzed data from 121 individuals with GRIN2A variants.
The data linked variants to early-onset psychiatric symptoms, including schizophrenia.
Initial treatment with L-serine showed improvements in psychiatric symptoms.