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GRIN2A Gene Linked to Increased Schizophrenia Risk

12/8/2025

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Story summary
  • Researchers identify the GRIN2A gene as a genetic risk factor for schizophrenia.
  • A Molecular Psychiatry study of 121 individuals shows 85 carried a GRIN2A variant, with 23 developing mental illness.
  • The results suggest higher risk for carriers and challenge the view that mental disorders are polygenic.
  • Earlier L-serine trials showed promise for NMDA receptor deficiency in schizophrenia, but more research is needed.