StaffDNA Cure Bowl: Old Dominion vs. South Florida Preview

The StaffDNA Cure Bowl features a compelling clash between the Old Dominion Monarchs and the South Florida Bulls on December 17, 2025, at Camping World Stadium. Both teams enter the game with identical 9-3 records, with South Florida favored by 3.5 points. This matchup showcases two of the nation’s most productive dual-threat quarterbacks: Colton Joseph of Old Dominion and Byrum Brown of South Florida.

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Both teams are known for their offensive capabilities, with Old Dominion averaging 32.7 points per game and South Florida leading with 43.0 points per contest. The Bulls' higher scoring average and their experience in a more competitive conference contribute to their status as favorites. However, South Florida has struggled against high-scoring offenses, as evidenced by their 4-0 record on the OVER when facing teams that average over 30 points.

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The betting line indicates a total of 53.5 points for the game. Given both teams' offensive strengths, there is potential for a high-scoring affair. However, analysts suggest caution, noting that Old Dominion may not match the offensive dynamism of other high-scoring teams in South Florida's conference. The recommendation is to consider betting on the UNDER 53.5.

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The StaffDNA Cure Bowl promises an exciting matchup between two capable teams led by dynamic quarterbacks. With both Old Dominion and South Florida looking to secure their third consecutive bowl-game victory, fans can expect a competitive and high-stakes game. As the teams prepare to clash, the performance of Colton Joseph and Byrum Brown will likely be pivotal in determining the outcome.

Sports Illustrated