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Study: Lipoic Acid May Slow Gray Matter Loss in MS

12/17/2025

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Summary

Story summary

A two-year trial with 54 patients taking 1,200 milligrams daily and 61 on placebo found that lipoic acid may slow gray matter loss in progressive multiple sclerosis.
Magnetic resonance imaging (MRI) scans showed reduced brain atrophy, while walking speed remained unchanged.
Lead researcher Dr. Rebecca Spain said the results suggest potential benefits despite lipoic acid's limited ability to cross the blood-brain barrier.

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Story summary

A two-year trial with 54 patients taking 1,200 milligrams daily and 61 on placebo found that lipoic acid may slow gray matter loss in progressive multiple sclerosis.
Magnetic resonance imaging (MRI) scans showed reduced brain atrophy, while walking speed remained unchanged.
Lead researcher Dr. Rebecca Spain said the results suggest potential benefits despite lipoic acid's limited ability to cross the blood-brain barrier.