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Story summary
- The San Francisco 49ers (10-4) will face the Indianapolis Colts (8-6) at Lucas Oil Stadium on December 22, with the game airing on ESPN at 8:15 PM ET.
- Philip Rivers will start for the Colts.
- The Colts remain in playoff contention after a difficult stretch.
- The 49ers are favored by 5.5 points.
- Analysts are divided about the outcome, with some predicting a 49ers win and others expecting a Colts upset.
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