Story perspectives

Personalized Screening Outperforms Mammograms in Cancer Detection

12/19/2025

50 11

Summary

Story summary

The Journal of the American Medical Association (JAMA) reports that the WISDOM trial found personalized, risk-based screening can detect tumors while reducing advanced cancers compared with annual mammograms.
The trial included 46,000 women aged 40 to 74 and divided participants into four risk groups to guide screening frequency.
Notably, 89% of participants opted for risk-based screening.
Despite the findings, some experts caution against changing guidelines and call for more data.

1 of 1

Story summary

The Journal of the American Medical Association (JAMA) reports that the WISDOM trial found personalized, risk-based screening can detect tumors while reducing advanced cancers compared with annual mammograms.
The trial included 46,000 women aged 40 to 74 and divided participants into four risk groups to guide screening frequency.
Notably, 89% of participants opted for risk-based screening.
Despite the findings, some experts caution against changing guidelines and call for more data.