Story perspectives

Parents Turn to Leucovorin Amid FDA Shortages, Experts Warn

12/20/2025

Summary

Story summary

Parents of autistic children are turning to leucovorin after a government endorsement.
Experts warn that evidence for leucovorin's effectiveness is limited, and no large trials have been conducted.
The U.S. Food and Drug Administration (FDA)'s focus on cerebral folate deficiency has left parents frustrated as they struggle to obtain prescriptions amid reported shortages.
Some parents resort to weaker folate supplements, while doctors warn of no official leucovorin guidelines.

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Story summary

Parents of autistic children are turning to leucovorin after a government endorsement.
Experts warn that evidence for leucovorin's effectiveness is limited, and no large trials have been conducted.
The U.S. Food and Drug Administration (FDA)'s focus on cerebral folate deficiency has left parents frustrated as they struggle to obtain prescriptions amid reported shortages.
Some parents resort to weaker folate supplements, while doctors warn of no official leucovorin guidelines.