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Study: Megestrol Boosts Anti-Estrogen Therapy in Breast Cancer

1/6/2026

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Summary

Story summary

A January 5, 2026 study suggests megestrol may enhance anti-estrogen therapy for ER-positive breast cancer.
Women taking megestrol with letrozole showed slower tumor growth.
The trial enrolled 198 ER-positive breast cancer patients assigned to different treatment groups for two weeks.
Lower-dose megestrol yielded similar effectiveness with fewer side effects than a higher dose.
Further research is needed to determine long-term benefits.

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Story summary

A January 5, 2026 study suggests megestrol may enhance anti-estrogen therapy for ER-positive breast cancer.
Women taking megestrol with letrozole showed slower tumor growth.
The trial enrolled 198 ER-positive breast cancer patients assigned to different treatment groups for two weeks.
Lower-dose megestrol yielded similar effectiveness with fewer side effects than a higher dose.
Further research is needed to determine long-term benefits.