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Genetic Insights Into Super Agers' Cognitive Resilience Uncovered

1/21/2026

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Summary

Story summary

Researchers from Vanderbilt University identified genetic factors linked to cognitive resilience in super agers.
They found that super agers are 68% less likely to carry the APOE-?4 gene and 28% more likely to have APOE-?2.
The study involved over 18,000 participants and aims to enhance understanding of Alzheimer's prevention and treatment.
The findings encourage further exploration of the super-ager phenotype in relation to cognitive health.

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Story summary

Researchers from Vanderbilt University identified genetic factors linked to cognitive resilience in super agers.
They found that super agers are 68% less likely to carry the APOE-?4 gene and 28% more likely to have APOE-?2.
The study involved over 18,000 participants and aims to enhance understanding of Alzheimer's prevention and treatment.
The findings encourage further exploration of the super-ager phenotype in relation to cognitive health.