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Vagus Nerve Stimulation Shows Promise for Depression Relief

1/26/2026

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Summary

Story summary

Washington University School of Medicine researchers find vagus nerve stimulation may improve outcomes for treatment-resistant depression.
The RECOVER trial enrolled nearly 500 participants, many unable to work due to depression.
After one year, about 69% of participants with activated devices improved.
More than 80% retained benefits at two years.
Findings could prompt coverage expansion by the U.S. Centers for Medicare and Medicaid Services (CMS).

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Story summary

Washington University School of Medicine researchers find vagus nerve stimulation may improve outcomes for treatment-resistant depression.
The RECOVER trial enrolled nearly 500 participants, many unable to work due to depression.
After one year, about 69% of participants with activated devices improved.
More than 80% retained benefits at two years.
Findings could prompt coverage expansion by the U.S. Centers for Medicare and Medicaid Services (CMS).