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Study: Psilocybin Alters Neuronal Firing, Boosts Antidepressant Effects

2/1/2026

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Summary

Story summary

A study indicates psilocybin and the selective 5-HT2A receptor agonist 25CN-NBOH may produce long-lasting antidepressant effects through persistent neuronal firing changes rather than structural growth.
A single dose altered neurons' electrical properties in rats for months, with no lasting structural changes.
Both psilocybin and 25CN-NBOH reduced immobility in a forced swim test, showing sustained behavioral improvements.
Researchers call for further study to understand how enduring effects emerge.

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Story summary

A study indicates psilocybin and the selective 5-HT2A receptor agonist 25CN-NBOH may produce long-lasting antidepressant effects through persistent neuronal firing changes rather than structural growth.
A single dose altered neurons' electrical properties in rats for months, with no lasting structural changes.
Both psilocybin and 25CN-NBOH reduced immobility in a forced swim test, showing sustained behavioral improvements.
Researchers call for further study to understand how enduring effects emerge.