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Oxybutynin Cuts Hot Flashes for Prostate Cancer Patients

2/4/2026

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Summary

Story summary

A Journal of Clinical Oncology study found oxybutynin reduces hot flashes in men on prostate cancer hormone therapy.
In 88 men, 5 mg daily yielded nearly seven fewer hot flashes per day versus two fewer with placebo.
Improvements appeared within the first week.
Lead researcher Dr. Bradley Stish called oxybutynin a new management option for this side effect.

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Story summary

A Journal of Clinical Oncology study found oxybutynin reduces hot flashes in men on prostate cancer hormone therapy.
In 88 men, 5 mg daily yielded nearly seven fewer hot flashes per day versus two fewer with placebo.
Improvements appeared within the first week.
Lead researcher Dr. Bradley Stish called oxybutynin a new management option for this side effect.