Back to today’s briefing

Story perspectives

Key Skin Gene ZNF750 Discovered Vital for Immune Defense

2/5/2026

34 2

Summary

Story summary

Ben-Gurion University of the Negev researchers identify the gene ZNF750 as vital for skin immune defense.
The study, published in Cell Reports, shows ZNF750 regulates IL-34, a survival signal for Langerhans cells.
Removing ZNF750 from skin cells in engineered mice leads to a significant decline in Langerhans cells.
The findings indicate skin cells actively support immune cells, and disruptions may contribute to psoriasis and atopic dermatitis.

1 of 1

Story summary

Ben-Gurion University of the Negev researchers identify the gene ZNF750 as vital for skin immune defense.
The study, published in Cell Reports, shows ZNF750 regulates IL-34, a survival signal for Langerhans cells.
Removing ZNF750 from skin cells in engineered mice leads to a significant decline in Langerhans cells.
The findings indicate skin cells actively support immune cells, and disruptions may contribute to psoriasis and atopic dermatitis.