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Story perspectives

New CRISPR Tool Targets Antibiotic Resistance, Offers Hope

2/7/2026

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Story summary
  • Researchers at UC San Diego have developed pPro-MobV, a CRISPR-based tool to remove antibiotic-resistance elements from bacterial populations.
  • The approach spreads the disabling elements through bacterial mating and within biofilms, which resist conventional antibiotics.
  • Antibiotic resistance is escalating into a global health crisis, with projections of more than 10 million deaths per year by 2050.
  • The innovation holds promise for healthcare, environmental cleanup, and microbiome engineering.