Story perspectives

Targeting Fungal Metabolism Could Revolutionize Antifungal Therapies

2/8/2026

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Summary

Story summary

Researchers led by Sriram Varahan at the CSIR–Centre for Cellular and Molecular Biology (CCMB) in Hyderabad show that fungal metabolism drives the yeast-to-filament transition.
The transition is driven by sugar breakdown that yields sulfur-containing amino acids needed for invasion.
The findings suggest targeting fungal metabolism could enable new antifungal therapies amid rising drug resistance.
This strategy may improve outcomes for human health and for food security.

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Story summary

Researchers led by Sriram Varahan at the CSIR–Centre for Cellular and Molecular Biology (CCMB) in Hyderabad show that fungal metabolism drives the yeast-to-filament transition.
The transition is driven by sugar breakdown that yields sulfur-containing amino acids needed for invasion.
The findings suggest targeting fungal metabolism could enable new antifungal therapies amid rising drug resistance.
This strategy may improve outcomes for human health and for food security.