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Story perspectives

Enlicitide Cuts LDL Cholesterol 60% in Major Trial

2/10/2026

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Story summary
  • Enlicitide reduced LDL cholesterol by about 60% versus placebo in a phase three trial of 2,909 at-risk patients.
  • The findings suggest enlicitide could help millions in the United States who struggle to control cholesterol.
  • Dr. Ann Marie Navar led the study, funded by Merck & Co. Inc, and published in The New England Journal of Medicine.
  • If approved by the FDA, enlicitide may enhance prevention of heart attacks and strokes.