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Story perspectives

Promising Gene Therapy Shrinks Lung Cancer Tumors

2/12/2026

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Story summary
  • A gene therapy for lung cancer has shown promise by shrinking tumors with immune-boosting genes delivered to lung cells.
  • Krystal Biotech developed the therapy using a modified herpes virus, fast-tracked by the U.S. Food and Drug Administration (FDA).
  • In trials, tumor size reduced in three of eleven patients; five others halted growth.
  • The approach is limited to lung tumors; ongoing trials will involve about 250 patients testing combinations.