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Y Chromosome Loss Linked to Serious Health Risks in Men

2/14/2026

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Summary

Story summary

Research shows men lose the Y chromosome with age, with about 40% at age 60 and 57% at age 90.
The absence of the Y chromosome is linked to higher risks of cardiovascular disease, Alzheimer's, and cancers.
Some evidence suggests Y chromosome loss may directly affect health outcomes.
The Y chromosome contains coding and non-coding genes that regulate other genes, potentially affecting immune function and heart health.

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Story summary

Research shows men lose the Y chromosome with age, with about 40% at age 60 and 57% at age 90.
The absence of the Y chromosome is linked to higher risks of cardiovascular disease, Alzheimer's, and cancers.
Some evidence suggests Y chromosome loss may directly affect health outcomes.
The Y chromosome contains coding and non-coding genes that regulate other genes, potentially affecting immune function and heart health.