Story perspectives

Single DMT Dose Shows Promise for Treatment-Resistant Depression

2/16/2026

Summary

Story summary

A small clinical trial showed that a single dose of dimethyltryptamine (DMT) with psychotherapy reduces symptoms of major depressive disorder.
The study involved 34 participants with treatment-resistant depression, and those treated with DMT reported improvements for six months.
Dr. David Erritzoe noted DMT's potential to enhance psychotherapy by helping patients break negative thought patterns while concerns remain about safe rollout in the UK, particularly the influence of private clinics.

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Story summary

A small clinical trial showed that a single dose of dimethyltryptamine (DMT) with psychotherapy reduces symptoms of major depressive disorder.
The study involved 34 participants with treatment-resistant depression, and those treated with DMT reported improvements for six months.
Dr. David Erritzoe noted DMT's potential to enhance psychotherapy by helping patients break negative thought patterns while concerns remain about safe rollout in the UK, particularly the influence of private clinics.