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Breakthrough Compound May Reset Body's Circadian Clock

2/16/2026

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Summary

Story summary

A team of scientists in Japan identified Mic-628, a compound that may reset the body’s clock by activating the Per1 gene.
In mice, a single Mic-628 dose enabled adaptation to a new light-dark cycle in four days, compared with seven days for controls.
The findings point to a drug-based approach for circadian disruption while researchers plan further studies to assess safety and efficacy in humans.

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Story summary

A team of scientists in Japan identified Mic-628, a compound that may reset the body’s clock by activating the Per1 gene.
In mice, a single Mic-628 dose enabled adaptation to a new light-dark cycle in four days, compared with seven days for controls.
The findings point to a drug-based approach for circadian disruption while researchers plan further studies to assess safety and efficacy in humans.