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Story perspectives

Y Chromosome Loss Linked to Heart Disease Risk

2/18/2026

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Story summary
  • The loss of the Y chromosome (mLOY) in men is linked to a higher risk of coronary artery disease.
  • Inflammation and plaque buildup exacerbate the risk associated with mLOY.
  • Carotid arteries are less affected by mLOY than coronary arteries.
  • mLOY may contribute to other health issues, including Alzheimer's disease and kidney disease.
  • Blood tests detecting mLOY could enable better monitoring and targeted treatments for at-risk men, potentially improving cardiovascular care.