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Psychedelic DMT Shows Promise for Lasting Depression Relief

2/20/2026

Summary

Story summary

Imperial College London reported that a single dose of dimethyltryptamine (DMT) combined with psychotherapy produced significant and lasting improvements in patients with major depressive disorder.
The study enrolled 34 participants and found symptom relief lasting up to six months.
By three months, 47% of participants achieved remission.
Future trials are planned, but regulatory hurdles remain, as evidenced by recent FDA rejections of psychedelic treatments.

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Story summary

Imperial College London reported that a single dose of dimethyltryptamine (DMT) combined with psychotherapy produced significant and lasting improvements in patients with major depressive disorder.
The study enrolled 34 participants and found symptom relief lasting up to six months.
By three months, 47% of participants achieved remission.
Future trials are planned, but regulatory hurdles remain, as evidenced by recent FDA rejections of psychedelic treatments.