Story perspectives

New CRISPR System Targets Antibiotic Resistance Genes

2/24/2026

Summary

Story summary

Researchers at the University of California San Diego developed a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based system, pPro-MobV, to remove antibiotic resistance traits amid a global health crisis projecting over 10 million deaths annually by 2050.
It uses a genetic cassette to disrupt resistance genes and enable spread.
It has shown effectiveness in biofilms, which are difficult to treat.
The researchers plan to combine pPro-MobV with engineered bacteriophages.

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Story summary

Researchers at the University of California San Diego developed a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based system, pPro-MobV, to remove antibiotic resistance traits amid a global health crisis projecting over 10 million deaths annually by 2050.
It uses a genetic cassette to disrupt resistance genes and enable spread.
It has shown effectiveness in biofilms, which are difficult to treat.
The researchers plan to combine pPro-MobV with engineered bacteriophages.