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Vitamin B3 Therapy Extends Lifespan in Mice with Genetic Disorder

2/26/2026

Summary

Story summary

Gladstone Institutes researchers have developed a vitamin-based approach to treating genetic diseases, showing that high-dose vitamin B3 can significantly extend the lifespan of mice with NAXD deficiency.
The therapy eliminated symptoms and normalized vital molecules in the treated mice.
Lead investigator Isha Jain of the Gladstone Institutes emphasizes early diagnosis and urges including NAXD in newborn screening.
The team plans to explore other vitamins for potential treatments.

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Story summary

Gladstone Institutes researchers have developed a vitamin-based approach to treating genetic diseases, showing that high-dose vitamin B3 can significantly extend the lifespan of mice with NAXD deficiency.
The therapy eliminated symptoms and normalized vital molecules in the treated mice.
Lead investigator Isha Jain of the Gladstone Institutes emphasizes early diagnosis and urges including NAXD in newborn screening.
The team plans to explore other vitamins for potential treatments.