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Christina Applegate Opens Up About Life with MS

3/3/2026

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Story summary
  • Christina Applegate, the actress, reveals she has multiple sclerosis in the memoir You with the Sad Eyes, published March 3, 2026.
  • Diagnosed in June 2021, Applegate describes severe pain, exhaustion, and loss of mobility.
  • Applegate states, "This disease has robbed me of who I am," highlighting the personal impact.
  • Weight gain from treatment bothers Applegate more than the disease itself, while she finds strength in her daughter Sadie.