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Older Mice Microbiome Boosts Fertility in Younger Mice

3/3/2026

Summary

Story summary

A University of Southern California study shows fecal transplants from older female mice improve ovarian function and fertility in younger mice.
Researchers report improved gene expression in ovarian cells and reduced aging-related inflammation after the older microbiome transfer.
All young mice with the older microbiome produced offspring, unlike many that received younger microbiota, suggesting potential fertility benefits and the need for human studies.

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Story summary

A University of Southern California study shows fecal transplants from older female mice improve ovarian function and fertility in younger mice.
Researchers report improved gene expression in ovarian cells and reduced aging-related inflammation after the older microbiome transfer.
All young mice with the older microbiome produced offspring, unlike many that received younger microbiota, suggesting potential fertility benefits and the need for human studies.