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Story summary
- Three genes—PKNOX1, BACH1, and GABPA—regulate gene activity in the developing brain of individuals with Down syndrome.
- Their regulation disrupts networks for learning and memory, with significant changes in fetal brain tissue.
- Lowering the activity of these regulators allowed some target genes to return to typical levels.
- Lab models showed promise but missed developmental changes, underscoring the need for further research into brain function and Alzheimer's risk.
