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Cortical Labs Pioneers Biological Computing with Human Neurons

3/15/2026, 11:32:58 PM

The Emergence of Biological Data Centers

Cortical Labs, an Australian biotech startup, is advancing the field of biological computing with its CL1 system, which utilizes 200,000 living human neurons. The company has demonstrated the ability of these neurons to learn and play the video game Doom, marking a significant leap from earlier attempts to teach them simpler games like Pong. As reported by Bloomberg, Cortical Labs is now developing biological data centers in Melbourne, Australia, and Singapore, aiming to replace traditional silicon-based processors with biological computers that consume significantly less power.

Innovative Technology and Applications

The CL1 system operates by sending electrical signals to neurons derived from human blood stem cells, with chips recording the neurons' responses. Cortical Labs claims that each CL1 unit requires less power than a handheld calculator, offering a more energy-efficient alternative to conventional AI processors. CEO Hon Weng Chong emphasizes that biological computers can learn from their environments and devise novel solutions, potentially outperforming classical computers in certain tasks.

Learning Capabilities and Future Potential

The neurons in the CL1 system have shown the ability to engage with complex tasks, such as navigating the challenges of Doom. Within a week of training, the neurons demonstrated basic gameplay skills, including targeting and firing at enemies. While the current performance is comparable to that of a novice player, the system's learning capabilities are expected to improve as researchers refine the encoding and reward mechanisms. Cortical Labs is inviting the scientific community to explore and enhance these learning processes through an open API.

Criticism and Challenges

Despite the promising advancements, there are significant challenges and skepticism surrounding biological computing. Critics point out that the practical applications of the CL1 system remain unclear, and it has yet to demonstrate computational capabilities that rival those of established data center chips. Additionally, the biological nature of the systems introduces complexities in maintenance, such as the need for regular fluid changes and gas adjustments to sustain the neurons' environment.

Official Statements and Responses

Cortical Labs has expressed confidence in the potential of biological computing to complement or even rival traditional algorithms in specific applications. The company is also aware of the environmental concerns associated with conventional AI data centers, which consume vast amounts of energy and resources. Chong has noted that the biological data centers could provide a more sustainable solution to these issues.

What's Next for Biological Computing?

As Cortical Labs continues to develop its technology, the future of biological computing appears to hold promise beyond gaming. Potential applications could extend into data analysis, robotics, and neuroscience, where the unique properties of neurons may offer advantages in adaptability and pattern recognition. The company envisions a future where living intelligence and digital infrastructure evolve together, paving the way for innovative solutions in various fields.

Verbatim Quotes

  • “We remove the fluid every 24 hours,” — Hon Weng Chong, CEO of Cortical Labs
  • “Yet the learning loop is real and improvable (via a public API).” — Cortical Labs statement on CL1 capabilities
  • “Refine encoding schemes that better map game states to neural stimuli Design richer reward signals to stabilize and speed learning Establish fair benchmarks to compare bio-computers with silicon models What the future holds Beyond gaming, this hybrid approach invites new strategies for data analysis, robotics, and neuroscience.” — Cortical Labs overview of future applications