Story perspectives

Sertraline Shows Promise for Rare Post-Orgasm Illness

3/17/2026

Summary

Story summary

The Journal of Sexual Medicine reports two men with post-orgasmic illness syndrome (POIS) who improved after sertraline treatment.
Two patients, a 28-year-old man and a 29-year-old man, experienced fatigue and cognitive fog after ejaculation and muscle pain with premature ejaculation, respectively.
Researchers caution that the findings come from only two cases, which limits significance and prompts calls for controlled trials to assess sertraline's effectiveness and identify biomarkers.

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Story summary

The Journal of Sexual Medicine reports two men with post-orgasmic illness syndrome (POIS) who improved after sertraline treatment.
Two patients, a 28-year-old man and a 29-year-old man, experienced fatigue and cognitive fog after ejaculation and muscle pain with premature ejaculation, respectively.
Researchers caution that the findings come from only two cases, which limits significance and prompts calls for controlled trials to assess sertraline's effectiveness and identify biomarkers.