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Story summary
- The study identifies significant single-nucleotide polymorphisms linked to bipolar disorder (BPD) through genome-wide association study (GWAS) and expression quantitative trait loci (eQTL) analyses.
- It analyzes the association between PBX1 expression and the rs4442348 genotype in excitatory neurons, using data from 983 samples.
- The genomic plots combine lead SNPs, fine-mapping SNPs, and epigenomic data.
- The study identifies brain cell types involved, including excitatory neurons, inhibitory neurons, and microglia, among others.
