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Y Chromosome Loss in Men Linked to Serious Health Risks

3/21/2026

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Summary

Story summary

Loss of the Y chromosome in older men links to higher risks of cardiovascular disease, neurodegenerative disorders, and cancer.
Mosaicism affects about 40% of men in their 60s and 57% by age 90.
Mosaicism can drive faster cell growth and influence tumor behavior.
Men with more Y-deficient cells face higher heart-attack risk and worse COVID outcomes.
The Y chromosome, once thought limited, may regulate genes and immune response.

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Story summary

Loss of the Y chromosome in older men links to higher risks of cardiovascular disease, neurodegenerative disorders, and cancer.
Mosaicism affects about 40% of men in their 60s and 57% by age 90.
Mosaicism can drive faster cell growth and influence tumor behavior.
Men with more Y-deficient cells face higher heart-attack risk and worse COVID outcomes.
The Y chromosome, once thought limited, may regulate genes and immune response.