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Story summary
- Kyoto University and RIKEN researchers identified a mechanism in which the protein DHX29 regulates gene expression by monitoring codon usage in mRNA.
- DHX29 stabilizes mRNAs enriched in non-optimal codons, which are translated less efficiently.
- Using CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) screening and cryo-electron microscopy, the team showed DHX29 interacts with ribosomes to control degradation of these transcripts and plans to study DHX29's role in health and disease.
