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Story summary
- University College London (UCL) researchers report that the APOE gene accounts for 72% to 93% of Alzheimer's disease cases.
- The study, published in npj Dementia, highlights the ?3 variant alongside the ?4 variant.
- Analyzing data from over 460,000 individuals, researchers suggest APOE could drive future treatments.
- Not all high-risk carriers develop dementia, despite the strong genetic link, and this reflects the genetics–environment interplay.
