Story perspectives

Study Finds Genes and Metformin May Control HIV Without ART

3/24/2026

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Researchers Identify HIV Genes

Researchers identified two genes, DDIT4 and ZNF254, that help some people control HIV without ongoing ART.
Higher levels of these genes correlate with delayed HIV rebound after ART cessation.
Metformin, a diabetes drug, can raise DDIT4 levels and may aid HIV suppression through a 'block and lock' approach.
Future trials will test metformin during and after ART to reduce chronic inflammation and improve health for people living with HIV.

Left

Lianne Faces HIV Challenges

Lianne, a 24-year-old sex worker in Eswatini, reflects on losing her parents to AIDS, earning under £25 weekly, and lacking HIV preventive medication.
The introduction of lenacapavir, a long-lasting injection, offers hope as the United Nations aims to deliver it to two million people by 2028, though funding concerns persist.
In the United States, 18 states have restricted AIDS Drug Assistance Programs, a move advocates say disproportionately affects Black communities.

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Researchers Identify HIV Genes

Researchers identified two genes, DDIT4 and ZNF254, that help some people control HIV without ongoing ART.
Higher levels of these genes correlate with delayed HIV rebound after ART cessation.
Metformin, a diabetes drug, can raise DDIT4 levels and may aid HIV suppression through a 'block and lock' approach.
Future trials will test metformin during and after ART to reduce chronic inflammation and improve health for people living with HIV.

1 / 2