Full Breakdown
Online Tool Enhances Genetic Risk Communication for Cancer Patients and Families
3/25/2026, 3:00:09 PM
Introduction to Genetic Risk Communication
A new web-based intervention, named Genetic Information and Family Testing (GIFT), has been developed to assist cancer patients in sharing their inherited genetic risks with family members. This initiative addresses a significant gap in cancer care, where oncologists primarily focus on the individual patient, often neglecting the potential implications for their relatives. According to Steven J. Katz, M.D., M.P.H., a researcher at the University of Michigan Health Rogel Cancer Center, germline genetic testing results can significantly impact the health of family members, making it crucial to facilitate communication about these risks.
The GIFT Intervention
The GIFT platform provides educational resources and decision support to help cancer survivors communicate genetic testing information to their first- and second-degree relatives. The intervention was tested with 414 cancer survivors diagnosed in 2018-2019 who carried a pathogenic variant. Participants were randomized into two groups: one receiving online-only support and the other having access to a human navigator, alongside options for free or $50 genetic testing. Results indicated that approximately 20% of patients invited relatives to participate, with one-third of those relatives enrolling. Notably, 90% of enrolled relatives opted for genetic testing, and those offered free testing were twice as likely to proceed, although overall participation rates remained low.
Importance of Family Communication
The study highlights the critical need for effective communication regarding genetic risks among family members. In a related study involving 1,767 women with breast, ovarian, or uterine cancer, it was found that while 80% of patients consulted a genetic counselor, only 57% received advice on how to share results with family. This gap underscores the necessity for tools like GIFT, which can empower patients to take the initiative in sharing their genetic information.
Future Developments
The research team is planning a second iteration of the GIFT tool that will incorporate an AI assistant to further personalize genetic risk information and enhance communication between patients and their families. Lawrence C. An, M.D., co-director of Rogel's Center for Health Communications Research, noted that participants found the platform user-friendly and effective without needing a navigator's assistance. This reflects a growing trend in utilizing technology to improve patient engagement and address unmet needs in cascade genetic testing.
Conclusion
The GIFT intervention represents a promising approach to addressing the challenges of sharing genetic risk information among cancer patients and their families. As the number of patients undergoing genetic testing continues to rise, tools that facilitate family communication about inherited risks will be essential in promoting informed decision-making and potentially altering cancer screening and prevention strategies for relatives.
