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MIT Study Reveals 30% Silent Synapses in Adult Mice

3/30/2026

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Story summary
  • Massachusetts Institute of Technology (MIT) neuroscientists have found that about 30% of synapses in the adult mouse cortex are silent.
  • They used the eMAP technique to reveal filopodia hosting these inactive synapses.
  • By pairing glutamate release with electrical signals, they activated the silent synapses.
  • The results imply the adult brain retains flexible learning connections, with aging potentially reducing memory adaptability.