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Australian Neurons Learn to Play Doom, Advancing Biological Computing

4/1/2026

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Summary

Story summary

Cortical Labs in Australia taught 200,000 living human neurons to play the video game Doom, as part of developing a biological computer to enhance drug testing and treatment personalization.
The neurons, derived from blood cells, showed basic learning behaviors like seeking enemies and shooting, though their performance was limited.
The researchers used a feedback loop that rewarded correct actions and punished mistakes to train the neurons.

History

Historical Context

The development of biological computing began in 1951 when researchers at the University of Illinois created the first biocomputer using living neurons for calculations. This innovation laid the groundwork for modern neurotechnology, exemplified by Cortical Labs teaching 200,000 human neurons to play Doom. Such advancements could transform drug testing and treatment personalization, highlighting the synergy between biology and computing.

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Story summary

Cortical Labs in Australia taught 200,000 living human neurons to play the video game Doom, as part of developing a biological computer to enhance drug testing and treatment personalization.
The neurons, derived from blood cells, showed basic learning behaviors like seeking enemies and shooting, though their performance was limited.
The researchers used a feedback loop that rewarded correct actions and punished mistakes to train the neurons.

1 / 2