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Fluvoxamine Reduces Long COVID Fatigue, Study Finds

4/1/2026

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Story summary
  • A trial published in the Annals of Internal Medicine found fluvoxamine reduces fatigue in adults with long COVID, with a 99% probability of outperforming placebo and improving quality of life.
  • The trial enrolled 399 participants in Brazil with fatigue for at least 90 days post-infection.
  • Metformin showed no meaningful benefits for established long COVID fatigue.
  • Researchers call for studies to understand fluvoxamine's mechanisms and role in treating long COVID.