Story perspectives

Brain Connectivity May Predict Antidepressant Response in Depression

4/3/2026

Summary

Story summary

A study in npj Mental Health Research indicates a brain-network signal may predict antidepressant responses in major depression.
Researchers analyzed brain scans from 4,271 participants, finding reduced connectivity between medial prefrontal and posterior cingulate cortices linked to outcomes.
Baseline connectivity could distinguish future responders from non-responders.
The authors, led by Kaizhong Zheng and Liangjun Chen, propose targeting the default mode network to improve treatment.
Limitations include excluding electroconvulsive therapy and psychotherapy.

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Story summary

A study in npj Mental Health Research indicates a brain-network signal may predict antidepressant responses in major depression.
Researchers analyzed brain scans from 4,271 participants, finding reduced connectivity between medial prefrontal and posterior cingulate cortices linked to outcomes.
Baseline connectivity could distinguish future responders from non-responders.
The authors, led by Kaizhong Zheng and Liangjun Chen, propose targeting the default mode network to improve treatment.
Limitations include excluding electroconvulsive therapy and psychotherapy.