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Story summary
- The study, published in Nature Aging, shows the APOE4 (apolipoprotein E4) gene variant significantly increases Alzheimer's risk by altering neuron activity years before symptoms appear.
- In young mice, APOE4 produced smaller, hyperactive neurons in the hippocampus linked to Nell2.
- Misha Zilberter (Gladstone Institute) leads the study, which is the first to examine APOE4's neuron effects across ages.
- Blocking Nell2 production reversed neuron damage, suggesting a pathway for future Alzheimer's treatments.
