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Story summary
- Bar-Ilan University scientists used CRISPR to modify a regulatory DNA region called Enh13, reversing the sex of XX mice.
- The modification targets a genetic switch that controls Sox9, essential for testis development.
- The findings, published in Nature Communications, show XX mice developed as males, suggesting a mechanism for Differences of Sex Development in humans.
- Dr. Nitzan Gonen of Bar-Ilan University emphasized that this genetic insight could improve clinical care.
