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Study Links Non-Nutritive Sweeteners to Metabolic Issues in Mice

4/10/2026

Summary

Story summary

Universidad de Chile researchers report that non-nutritive sweeteners sucralose and stevia may harm metabolic health across generations in mice.
They found changes in gut microbiome composition and gene expression related to metabolism and inflammation.
Male offspring of sucralose consumers showed impaired glucose tolerance.
Second-generation descendants had higher blood sugar in both sexes.
The researchers caution that the study does not prove causation and call for further research.

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Story summary

Universidad de Chile researchers report that non-nutritive sweeteners sucralose and stevia may harm metabolic health across generations in mice.
They found changes in gut microbiome composition and gene expression related to metabolism and inflammation.
Male offspring of sucralose consumers showed impaired glucose tolerance.
Second-generation descendants had higher blood sugar in both sexes.
The researchers caution that the study does not prove causation and call for further research.