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Story summary
- Bar-Ilan University researchers show that altering a single base in the Enh13 regulatory region can trigger female mice to develop male reproductive organs.
- The study, published in Nature Communications, links Enh13 changes to the Sox9 gene, essential for male development.
- Using CRISPR, researchers created mutations deleting three bases or adding one, causing XX mice to develop male genitalia and testes.
